EGFR and its downstream pathway regulate epithelial–mesenchymal transition, migration, and tumor invasion and that high EGFR expression is an independent predictor of poor prognosis in inflammatory breast cancer. Targeting EGFR enhances the chemosensitivity of tumor cells by rewiring apoptotic signaling networks in Triple-Negative Breast Cancer [17]. The gene discussed is EGFR; the disease is inflammatory breast carcinoma.