Bifidobacterium was found to be protective against CRC tumor development in murine models of CRC through the downregulation of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER-2), and prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 (PTGS-2 COX-2) (66, 67). This evidence concerns the gene PTGS2 and neoplasm.