In the present study, we focused on tau protein; however, it is reasonable to hypothesize that EV from infected cells contain other neurotoxic proteins and miRNA that are modulated by the viral infection, such as Aβ and pro-inflammatory cytokines, as well as viral protein and genome, that may affect neighbor cells predisposing them to AD-related neurodegenerative pathways. This evidence concerns the gene MAPT and Alzheimer disease.