MAPT and viral infectious disease: These results, in line with previous studies showing the occurrence of tau phosphorylation upon virus infection at T212, S214, AT100 (T212/S214), AT8 (T202/T205), and PHF (S396/S404) (26), highlight for the first time that HSV-1 could drive the phosphorylation of other ptau sites that are also found released via EV.