[11] A recent report showed that the Pelota‐Hbs1 RNA surveillance complex‐mediated NGD and NSD attenuated the disease of several viruses in the family Potyviridae by recognizing the viral conserved GA motif and mediating viral RNA degradation.[15] Furthermore, NMD factors, including UPF3 and SMG7, recognized the m6A readers‐viral m6A RNA complex for viral RNA degradation to limit virus infection in plants.[16] Thus, RQC‐dependent viral RNA degradation is thought to be a pivotal viral restriction mechanism. This evidence concerns the gene SMG7 and viral infectious disease.