However, a recent study analysed the effect of PARP7 knockout in EO771 mouse mammary cancer cells and in a preclinical syngenic tumour model, utilizing wild-type and catalytically inactive mutant Parp7H532A mice, and showed that loss of PARP7 function modestly reduced cancer cell proliferation, while not affecting tumour growth in immunodeficient mice. Here, TIPARP is linked to cancer.