ChIP enrichment analysis revealed the possible involvement of FOXM1, E2F1, E2F4, SOX2, KLF4, and MYBL2 transcription factors in the pathogenesis of PTCL because they may play a role in the deregulation of the ‘Core PTCL Expression Signature’ (Figure S9). Here, E2F1 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.