It acts as an endogenous inhibitor of calcineurin activity and thus may lead to hypertension through this path, given that a side effect of immunosuppressive medications that act as calcineurin inhibitors is hypertension [16]; moreover, CHP1 serves as an essential cofactor that supports the physiological activity of NHE family members, which are transmembrane proteins that act as a sodium–hydrogen antiporter. Here, CHP1 is linked to hypertensive disorder.