Emerging evidence suggests a bidirectional relationship between psoriasis and chronic periodontitis, supported by epidemiological studies indicating a higher prevalence of periodontitis among individuals with psoriasis and vice versa [2,3] Both conditions are chronic inflammatory diseases marked by dysregulated immune responses and altered cytokine profiles, particularly involving proinflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-17 (IL-17), which contribute to tissue damage and inflammation [4]. The gene discussed is TNF; the disease is psoriasis.