These findings corroborate the results found by Gerritsma et al. (2021), who followed 664 patients with SCD in the Netherlands and found that 60% of patients fulfilled at least one of the criteria for DHR (Hb increase < 1.5 g/dL post-transfusion or Hb less than pre-transfusion, dark urine, altered LDH results, and recurrence of vaso-occlusive crises) during transfusion follow-up [15]. Here, GSTM1 is linked to Schnyder corneal dystrophy.