Once again, individuals exposed to the disease, but free from infection, also presented cytophilic (IgG1 and IgG3) and non-cytophilic (IgG2) antibodies, as seen in the infected group; curiously, the highest frequency observed for IgG3 was from the CH for PvTRAP(P344-G374) with 72% of responders. The gene discussed is IGHG3; the disease is infection.