This is in line with a nationwide study reporting increased risk of valvular disease and heart failure in adults with OI compared to the general population.2 Furthermore, also consistent with the literature, collagen type I was highly expressed in the vascular wall.23 Next, we examined the expression of COL1A1 and COL1A2 in the heart. This evidence concerns the gene COL1A2 and osteogenesis imperfecta.