Kumazoe et al. demonstrated that EGCG3'”Me served as a natural agonist for the 67-kDa laminin receptor (67LR), effectively attenuated Toll-like receptor 4 (TLR4) expression through the upregulation of E3 ubiquitin-protein ring finger protein 216 (RNF216), thereby mitigating high insulinemia and hypertriglyceridemia induced by high-fat/high-sugar conditions. Here, TLR4 is linked to hypertriglyceridemia.