AKT1 and Insulin resistance: Curcumin inhibited the UPS function in 3 T3-L1 adipocytes, activated autophagy, reduced protein kinase B (Akt) protein levels, and concurrently inhibited insulin-stimulated Akt phosphorylation and membrane translocation of glucose transporter type 4 (GLUT4), which leading to the amelioration of insulin resistance (36).