Therefore, in cases where an inflammatory response persists with damaging pain, such as low back pain, back pain, autoimmune diseases - rheumatism, etc., or in cases of neuropathic pain, NGF induces sensitization of the peripheral and central systems, which can lead to nociceptive hypersensitivity and anisocoria, and analgesics that block NGF/TrKA signaling can be very effective in these pathologies (Hirose et al., 2016). This evidence concerns the gene NGF and rheumatic disorder.