CDKN2A and malignant colon neoplasm: Other studies found that CXCL8 is closely associated with the progression of colon cancer (Chen et al., 2019; Fang et al., 2022; Liu et al., 2022; Olivera et al., 2022), and the inhibition of P16INK4a expression also reduced the expression of CXCL8 (Buj et al., 2021).