For example, it was shown that the lipid metabolism in AD brain tissue is changed, including changes in the fatty acid composition (Nasaruddin et al., 2016; Yin, 2023), accumulation of cholesterol (Xiong et al., 2008; Ahmed et al., 2024), and the presence of the lipoprotein APOE4 isoform as risk factor for AD (Zhu et al., 2015; Lefterov et al., 2019; Miranda et al., 2022; Pires and Rego, 2023; Lozupone and Panza, 2024). This evidence concerns the gene APOE and Alzheimer disease.