The levels of p-JNK and p-ERK1/2 were also significantly upregulated in EpCAM+/− mice compared to WT group (p ≤ 0.01) although the p-p38 showed no significant difference between EpCAM+/− and WT groups (p = 0.192) (Figures 2B,C), indicating the increase of the sensitivity of EpCAM+/− mice to colitis. The gene discussed is EPCAM; the disease is colitis.