Association of CKD-MBD biomarkers and changes in estimated bone-strength indices at the femoral neck regions from baseline over up to a maximum of 2.5 years based on multivariate mixed model analysis adjusting for sex, age, duration of dialysis, cause of ESKD, serum cCa levels, serum phosphate levels, serum i-PTH levels, serum ALP levels, vitamin D use and calcimimetics use. The gene discussed is PTH; the disease is Marchiafava-Bignami disease.