VEGFA and neoplasm: Although this potential causal relationship needs demonstration, the concept is also supported by other studies showing that neutrophils mediate tumor angiogenesis (66, 67), and lymphangiogenesis in the footpad and LN in immunized mice by promoting the bioavailability of VEGF (68), a potent angiogenic factor also critical for the development of the LN vascular network (53, 54).