For example, in AD, immune cells and therefore microglia, if activated in a state of chronic inflammation, could be involved in the birth of the Aβ plaque by increasing its secretion, inducing the expression of interferon-induced transmembrane protein 3 (IFITM3) which improves the aggregation of β-amyloid plaque (44, 45). Here, IFITM3 is linked to Alzheimer disease.