Dual blocking of CD73-TGF-β promoted a variety of inflammatory TME, manifested by decreased levels of MDSCs and M2-like TAM, as well as significantly increased levels of DC activation, cytotoxic T cells, and B cells, accumulation of M1-like TAM, and secretion of TNF-α in triple-negative breast cancer (51). Here, NT5E is linked to triple-negative breast carcinoma.