CKS2 is significantly upregulated in gastric cancer, and high levels of CKS2 inhibit the expression of tumor suppressor factors p53 and p21 cip1, thereby promoting increased cell growth, while transfection of cancer cells with CKS2-siRNA to inhibit CKS2 can promote the expression of tumor suppressor genes (P50 and P21) and inhibit cell proliferation (40). This evidence concerns the gene TP53 and cancer.