CXCR4 and breast cancer: For instance, an Anti-CXCR4- targeted liposome encapsulating LCN2 siRNA effectively targets metastatic breast cancer cells and significantly blocks migration in triple-negative human breast cancer cells (88% for MDA-MB-436 and 92% for MDA-MB-231) along the CXCR4-CXCL12 axis (137).