DNMT1 and neoplasm: Additionally, overexpression of miR-503-3p in hUCMSC-derived exosomes inhibited tumor growth and suppressed the expression of MEST, which is involved in EC by cell proliferation, differentiation, and apoptosis (181) Another application example is exogenously transfected miR148b cancer-associated fibroblasts (CAFs)-derived exosomes, which suppress EC cell invasion and metastasis by targeting DNMT1 gene.