It should also be noted that human umbilical cord mesenchymal stem cell (hUCMSC)-derived exosomes may be a valuable tool for target-based therapies, namely engineered exosomes that, with tumor-suppressor miRNAs, can be delivered by hUCMSCs to EC cells and finally inhibit their proliferation (239) targeted EC cells overexpressing miR-302a exosomes and disrupted their migration proliferation and by suppressing cyclin D1 levels and inactivating the AKT signaling pathway (240). Here, AKT1 is linked to neoplasm.