miR-20b-5p could modulate vascular endothelial growth factor A (VEGFA) transcription by targeting hypoxia-inducible 4 factor 1-alpha (HIF1α), may act as a tumor suppressor by hindering MMP-2 expression, leading to cell cycle arrest, and also has a regulatory function in oxygen balance (195). This evidence concerns the gene MMP2 and neoplasm.