PIK3R1 and endometrium adenocarcinoma: The above model was used, and it was shown that the mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (Pik3ca) and phosphoinositide-3-kinase regulatory subunit 1 (Pik3r1) cooperate with PTEN loss to promote endometrial adenocarcinoma in mice.