On the other hand, the overexpression of Mcl-1 leads to apoptosis resistance and consequently results in liver damage and the development of hepatic fibrosis (Figure 2) [26, 71, 72], due to the involvement of BOK in hepatocarcinogenesis in mice models when diethylnitrosamine (DEN) was used. This evidence concerns the gene MCL1 and Hepatic fibrosis.