Furthermore, a study utilizing albumin-Cre (Alb-Cre)/Mcl-1flox/flox knockout mice showed that when Mcl-1 was deleted in the liver epithelium, it resulted in liver damage, apoptosis induction, and the development of HCC, for instance, even though absence of hepatitis evidences [25, 57, 58]. This evidence concerns the gene ALB and Hepatitis.