For CXCL12, no significant associations were reported between CXCL12 levels and ALS-FRS-R clinical either in CSF (Spearman r = 0.01107, P = 0.9425) or plasma (Spearman r = 0.064, P = 0.7317). The gene discussed is CXCL12; the disease is amyotrophic lateral sclerosis.