In the case of IP, although the AUC value was higher for CXCL12, no significant differences were reported when comparing the accuracy of NF-L or CXCL12 CSF levels (ΔArea 0.0431 ± 0.038, z = 1.1343, P = 0.257; Fig. 1E). This evidence concerns the gene NEFL and incontinentia pigmenti.