NEFL and amyotrophic lateral sclerosis: Nowadays, only increased levels of neurofilaments (NFs) in the CSF are considered the most useful biomarker in amyotrophic lateral sclerosis.6-9 However, increased levels of NF-L in the CSF are not specific to the disease, being increased in most of the neurological conditions.10-17 Given the lack of specificity in NF-L, our group has previously sought to identify novel molecules that could enhance the diagnosis of amyotrophic lateral sclerosis.