Of note, while a central role for HIF1 in macrophage glycolysis can be appreciated from aforementioned, silencing of HIF1α or HIF2α, or exaggerated HIF signaling by knockdown of its upstream regulators has many other cellular effects that complicate its use as intervention in atherosclerosis (Marsch et al., 2014; van Kuijk et al., 2022). The gene discussed is HIF1A; the disease is atherosclerosis.