IGF-1 also boosts GSH synthesis in neuroblastoma SH-SY5Y cells (a cell line model for ASD) by upregulating the expression of the glutamate-cysteine ligase modifier subunit (GCLM), which is mediated by increased nuclear factor erythroid 2-related factor 2 (Nrf2) protein in the nucleus. This evidence concerns the gene NFE2L2 and neuroblastoma.