Melanoma risk is also thought to be increased in cancer predisposition syndromes including Cowden syndrome, Li-Fraumeni syndrome, and hereditary breast and ovarian cancer syndrome, caused by pathogenic variants in phosphatase and tensin homolog, tumor protein 53, and BRCA1 and BRCA2, respectively.8 The gene discussed is BRCA2; the disease is Hereditary breast and ovarian cancer syndrome.