For example, the lncRNA HOTTIP derived from the HOXA locus directly interacts with WD repeat-containing protein 5 (WDR5), thereby guiding the histone methyltransferase complex WDR5-MLL (myeloid/lymphoid leukemia) to the promoters of HOXA genes to promote gene transcription.121. The gene discussed is WDR5; the disease is lymphoid leukemia.