Phenobarbital-induced AIP mice have upregulated CYP2C40, CYP2C68, and CYP2C69, equivalent to human CYP2C8, CYP2C9, and CYP2C19 respectively (Nelson et al., 2004; Zanger et al., 2008), but downregulates CYP21A1 (Chen et al., 2019b), equivalent to human CYP21A2 or a homolog of CYP17A1 (−37), a crucial enzyme in corticosteroid and sex hormone synthesis (Idkowiak et al., 1993). Here, CYP2C9 is linked to autoimmune pancreatitis.