detected the H3K27ac epigenetic markers on active promoters and enhancers in NASH patients and found that genes correlated with xenobiotic, bile acid, and fatty acid metabolism, including coagulation, adipogenesis, and oxidative phosphorylation, showed markedly a reduced level of H3K27ac, while genes regarding TNF‐α signaling via NF‐κB, epithelial‐to‐mesenchymal transition (EMT), and inflammatory response demonstrated increased H3K27ac levels52 (Figure 6C). Here, NFKB1 is linked to metabolic dysfunction-associated steatohepatitis.