CDH1 and Pallister-Hall syndrome: E-cad suppression in PHs causes theirdifferentiation, while E-cad overexpression promotes PH maintenance[41, 131].Activation of the Wg/Wnt/β-catenin signalingpathway in Hml+ cells of the CZ has also been shown tosuppress the expression of the Tig ECM protein and affect plasmatocytematuration [132, 133], which is additional indication of the function of thissignaling pathway in the IZ cells.