ERBB2 and neoplasm: In this study, we designed a platform for detecting HER2-positive tumors basedon tumor-specific liposomes loaded with a genetically encoded BRET sensor(Fig. 1).The BRET sensor is NanoLuc-LSSmKate1, a hybridprotein based on the highly catalytic NanoLuc luciferase and the large Stokesshift red fluorescent protein LSSmKate1 (λex/λem = 463/624 nm)[23].