These studies will include creating genetically engineered mouse models to express APOE and MMP7 in a spatially controlled manner, conducting in vivo imaging and single‐cell RNA sequencing to observe the dynamics of immune cell interactions within the TME, and evaluating the impact of disrupting the CD14+APOE+ cells and MMP7+ tumour cell interaction on tumour growth and response to immunotherapy. This evidence concerns the gene CD14 and neoplasm.