These experiments will aim to confirm the causal relationship between the co‐location of CD14+APOE+ cells and MMP7+ tumour cells and immune resistance mechanisms, investigate the specific signalling pathways (MK, SEMA3 and MIF) identified in our study within a controlled animal model, and test potential therapeutic interventions targeting these interactions to assess their efficacy in overcoming immune resistance. Here, APOE is linked to neoplasm.