In order to explore whether Neuritin plays a role in the Schwann cell demyelination during WD is caused by regulating PI3K/Akt/mTOR pathway, we set up the ex vivo nerve explants model and found that an up‐regulation of PI3K, p‐Akt, p‐mTOR was revealed by western blotting in Neuritin group. Here, MTOR is linked to Wilson disease.