On the contrary, in the AHD(+) group, patients with the CC genotype of rs11841945 in KLF5 had lower SBP (P = 0.031) and DBP (P = 0.002) than those with the GG and GC genotypes (Supplementary Fig. 1 C and 1D, available online). Here, KLF5 is linked to mitochondrial DNA depletion syndrome 4a.