The fact that ANA-positive patients were more frequently oligoarthritis, DRB1*08 or DRB1*11 positive, female and had a younger age at onset (3 years vs 8 years) than ANA-negative patients further support the notion that ANA positivity is a genetically driven phenomenon associated with a specific subgroup of JIA patients. Here, BTG3 is linked to juvenile idiopathic arthritis.