Moreover, two CpGs displayed association in the individual-level analysis of incident CAD: cg06567227 and cg06714480 annotated to the gene body of SIM1 (SIM BHLH transcription factor 1) and to the 5′UTR of NEUROD1 (neuronal differentiation 1) and CERK (Ceramide Kinase), respectively. This evidence concerns the gene SIM1 and coronary artery disorder.