Three gene regions were found in EWAS of prevalent cerebrovascular diseases (CD) holding for multiple testing (FDR < 0.05): GPR158/GPR158-AS1, C5AR1, and EGFR, encoding a protein likely involved in G protein-coupled receptor activity/its antisense RNA, a receptor of complement 5a, and a growth factor receptor, respectively. The gene discussed is C5AR1; the disease is cerebrovascular disorder.