These proteins included established markers of AD like MAPT (encoding the tau protein) and neurogranin, but also proteins related to immune response (ITGAM, ITGB2 (both expressed in microglia) and MIF), apoptosis (CRKL and MP2K1) and calcium-dependent signaling (PPP3R1, part of the calcineurin complex). This evidence concerns the gene MIF and Alzheimer disease.