KDM6A and cardiovascular disorder: In cardiomyocytes, we see sex-related variation in genes related to cardiovascular disease and cardiomyocyte preservation, such as KCNJ3 (higher in males, associated with arrythmias45), GADD5G (higher in males, promotes cardiomyocyte apoptosis in heart failure46), KDM6A (higher in females, protects cardiomyocytes from hypoxia-induced apoptosis47), and DOK5 (higher in females, a driver in cardiomyocyte differentiation48).