SOCS6 and acute myeloid leukemia: To then test whether SCD activity and oleate levels regulate de novo fatty acid synthesis pathway in AML, we grew cells in the presence of oleate and noted decreased production of both SFA and MUFA (Fig. 5C and Supplementary Fig. 5A, B) which also correlated with a complete rescue of SSI-4-mediated decrease in viability, supporting the on-target efficacy of SSI-4 (Fig. 5D).