Likewise, in the TARGET-AML cohort, we detected a (subtle) negative correlation between the M2-predominance score and the T- and CD8+ T cell abundance in the BM (r = –0.25 [95% CI: –0.39 to –0.10], P = 0.002; r = –0.20 [95% CI: –0.35 to –0.05], P = 0.011, respectively; Fig. 2H and Fig. S2D), and a significantly decreased M2-predominance score in the immune-infiltrated compared to the immune-depleted group (P < 0.001.; Fig. 2I). This evidence concerns the gene CD8A and acute myeloid leukemia.