Intriguingly, the immunofluorescence assay revealed a reduction in the foci of BRCA1 and Rad51, two crucial proteins involved in DNA repair, in NLRP4-knockdown pancreatic cancer cells 6 h after olaparib removal (Fig. 3h and Extended Data Fig. 3a–d). Here, NLRP4 is linked to familial pancreatic carcinoma.