ChIP-qPCR experiments in pancreatic cancer cell lines confirmed significant H3K18ac enrichment in NOXO1 promoter region (Fig. 6f–h and Extended Data Fig. 6d), which was diminished upon NLRP4 knockdown (Fig. 6i), suggesting NLRP4’s regulation of H3K18ac at the NOXO1 promoter. Here, NOXO1 is linked to familial pancreatic carcinoma.