JAK2 and melanoma: Induction of the TEM from melanoma cells [34], transfer of miRNAs supporting 1-integrin-NF-kB signaling from metastatic liver cancer cells [35], improvement of breast cancer cell motility and ECM remodeling pathways [36], and activation of SOCS1/JAK2/STAT3 signaling from melanoma cells [37] (Fig. 1).