PI3K/AKT is also an important metastasis-related signalling pathway in ATC and PDTC, and PIK3CA mutation contributes to the recurrence and metastasis of ATC and PDTC [129]; however, whether PI3K/AKT is a common aggressive driver of metastasis in all subtypes of thyroid cancer needs to be further investigated. The gene discussed is PIK3CA; the disease is thyroid gland carcinoma.