SMARCA4 and acute lymphoblastic leukemia: Given that BRG1 occupies the activation transcriptional site of PPP2R1A and inhibits its expression, we speculate that BRG1 overexpression inhibits PP2A expression by suppressing PPP2R1A transcription, which activates PI3K/AKT signaling to promote the proliferation of B-ALL cells and inhibit apoptosis.