With regard to tumor subgroups, it is plausible that SOD1 inhibition might be especially effective in tumors with an intact mTORC1 sensor, i.e. tumors that effectively downregulate mTORC1 signaling in response to hypoxia and/or nutrient deprivation or in combination with mTORC1 inhibitors. The gene discussed is SOD1; the disease is neoplasm.