To test the hypothesis weather SOD1 activation could be a potential explanation for the known therapy resistance of GBs to mTORC1 inhibitors under conditions of the tumor microenvironment [25, 26], the combination therapy of the mTORC1 inhibitor rapamycin and the SOD1 inhibitor ATN-224 was tested under starvation conditions. This evidence concerns the gene SOD1 and neoplasm.