FABP5 and Alzheimer disease: When the downregulated genes in microglia of MNU-treated Trem2−/− retina was compared with markers of DAM identified in the brain of AD mouse [15], a group of 40 genes were found in common, including Spp1, Lpl, Mif, Fabp3 and Fabp5, which are related to lipid metabolism and phagocytosis (Fig. 5A, B).