HDAC1 and gastric cancer: To further investigate the mechanism of abnormal activation of TRIP13 in gastric cancer, a significant positive correlation between histone deacetylase 1 (HDAC1) and TRIP13 through analysis of the ENCORI database (Fig. 4A) was considered, inferring that HDAC1 might act as an upstream factor of TRIP13 to activate the expression of the latter.