To further investigate the mechanism of abnormal activation of TRIP13 in gastric cancer, a significant positive correlation between histone deacetylase 1 (HDAC1) and TRIP13 through analysis of the ENCORI database (Fig. 4A) was considered, inferring that HDAC1 might act as an upstream factor of TRIP13 to activate the expression of the latter. This evidence concerns the gene TRIP13 and gastric cancer.