Adults experiencing obesity and obese mice have greater concentrations of fasting asprosin compared to their lean counterparts (Ceylan et al., 2023; Duerrschmid et al., 2017; Romere et al., 2016) and subcutaneous administration of asprosin to mice increases food intake via activation of AgRP neurons and inhibition of POMC neurons that were prevented with ablation of AgRP neurons (Duerrschmid et al., 2017). The gene discussed is POMC; the disease is obesity due to melanocortin 4 receptor deficiency.