In humans, IL‐6 was moderately correlated with GLP‐1 (no relationship with ghrelin) following acute bouts of MICT, VICT, and SIT in young normal weight males (Islam et al., 2017), though in young lean sedentary males as well as those experiencing obesity there was no effect of exercise‐induced or adiposity‐related IL‐6 on GLP‐1, acylated ghrelin, or other appetite markers (Bornath et al., 2023). This evidence concerns the gene GHRL and obesity due to melanocortin 4 receptor deficiency.